Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Treatment of Typhoid Fever and Other Systemic Salmonelloses with Cefotaxime, Ceftriaxone, Cefoperazone, and Other Newer Cephalosporins

Garwin B. Soe and Gary D. Overturf
Reviews of Infectious Diseases
Vol. 9, No. 4 (Jul. - Aug., 1987), pp. 719-736
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4454162
Page Count: 18
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
Treatment of Typhoid Fever and Other Systemic Salmonelloses with Cefotaxime, Ceftriaxone, Cefoperazone, and Other Newer Cephalosporins
Preview not available

Abstract

Third-generation cephalosporins have been considered for the treatment of systemic salmonelloses because of emerging resistance among Salmonella species to ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole. Twelve patients with typhoid/paratyphoid fever, nine with nontyphoid salmonella bacteremia, and two with Salmonella meningitis were treated with cefotaxime; one leukemic patient with Salmonella dublin bacteremia received ceftizoxime. All infections were cured except for one in a patient with sickle cell anemia; this patient's illness recurred but was cured with a second course of cefotaxime followed by ceftriaxone. A review of the literature documented cures with cefotaxime in 50 of 61 patients with typhoid/paratyphoid fever, all of four with salmonella osteomyelitis, 12 of 14 with salmonella meningitis, and 44 of 49 with non-typhoid salmonella bacteremia. Ceftriaxone and cefoperazone cured, respectively, 23 of 25 and 32 of 33 patients with typhoid/paratyphoid fever. The relapse rates of typhoid fever treated with cefotaxime, ceftriaxone, and cefoperazone were 6%, 4%, and 0%, respectively. Cefotaxime, ceftriaxone, and cefoperazone are acceptable alternative antibiotics for the treatment of salmonelloses caused by multiresistant organisms.

Page Thumbnails

  • Thumbnail: Page 
719
    719
  • Thumbnail: Page 
720
    720
  • Thumbnail: Page 
721
    721
  • Thumbnail: Page 
722
    722
  • Thumbnail: Page 
723
    723
  • Thumbnail: Page 
724
    724
  • Thumbnail: Page 
725
    725
  • Thumbnail: Page 
726
    726
  • Thumbnail: Page 
727
    727
  • Thumbnail: Page 
728
    728
  • Thumbnail: Page 
729
    729
  • Thumbnail: Page 
730
    730
  • Thumbnail: Page 
731
    731
  • Thumbnail: Page 
732
    732
  • Thumbnail: Page 
733
    733
  • Thumbnail: Page 
734
    734
  • Thumbnail: Page 
735
    735
  • Thumbnail: Page 
736
    736