Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

4-Quinolones in the Treatment of Infections of the Central Nervous System

S. Ragnar Norrby
Reviews of Infectious Diseases
Vol. 10, Supplement 1. International Symposium on New Quinolones (Jan. - Feb., 1988), pp. S253-S255
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4454467
Page Count: 3
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
4-Quinolones in the Treatment of Infections of the Central Nervous System
Preview not available

Abstract

The literature concerning the penetration of new 4-quinolones into the cerebrospinal fluid (CSF) and brain tissue is reviewed as well as the few reports on clinical use of these antibiotics in the treatment of infections of the central nervous system (CNS). Pefloxacin has been found to penetrate well into the CSF of patients with normal or inflamed meninges as well as into brain tissue. Ciprofloxacin also penetrates into CSF, although not as well as pefloxacin. Two patients with meningitis due to Pseudomonas aeruginosa have been reported to have recovered after treatment with ciprofloxacin. Because of the spectrum limitations of quinolones, especially with regard to anaerobes and gram-positive aerobic cocci, these agents should not be considered for empiric use in CNS infections. They may, however, become alternatives in the rare cases of CNS infection caused by organisms resistant to other antibiotics.

Page Thumbnails

  • Thumbnail: Page 
S253
    S253
  • Thumbnail: Page 
S254
    S254
  • Thumbnail: Page 
S255
    S255