Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Recent Developments in β-Lactamase Research and Their Implications for the Future

Karen Bush
Reviews of Infectious Diseases
Vol. 10, No. 4, New Developments in Resistance to β-Lactam Antibiotics among Nonfastidious Gram-Negative Organisms (Jul. - Aug., 1988), pp. 681-690
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4454537
Page Count: 10
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
Recent Developments in β-Lactamase Research and Their Implications for the Future
Preview not available

Abstract

β-Lactamases, major determinants of bacterial resistance to β-lactam antibiotics, can be classified into specific molecular classes following identification of active-site amino acid or nucleotide sequences. The use of gene probes for epidemiologic purposes is becoming commoner. A semiempirical classification scheme has been proposed using substrate profiles and inhibition by clavulanic acid and aztreonam as criteria. Class 1 cephalosporinases are potently inhibited by aztreonam but poorly inhibited by clavulanate, whereas class 2 penicillinases and broad-spectrum β-lactamases have very poor affinities for aztreonam but are inhibited by clavulanic acid. Class 3 β-lactamases include the metallo-enzymes. Resistance to β-lactam antibiotics can be related to many β-lactamase-mediated phenomena, including increased frequency of β-lactamase production in clinical isolates, wider distribution of β-lactamase-mediating plasmids, production of multiple β-lactamases, induction of chromosomal class 1 cephalosporinases, selection of derepressed mutants for production of class 1 enzymes, leakage of β-lactamase from gram-negative organisms, functions of penicillin-binding proteins as β-lactamases, and identification of novel β-lactamases.

Page Thumbnails

  • Thumbnail: Page 
681
    681
  • Thumbnail: Page 
682
    682
  • Thumbnail: Page 
683
    683
  • Thumbnail: Page 
684
    684
  • Thumbnail: Page 
685
    685
  • Thumbnail: Page 
686
    686
  • Thumbnail: Page 
687
    687
  • Thumbnail: Page 
688
    688
  • Thumbnail: Page 
689
    689
  • Thumbnail: Page 
690
    690