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Molecular Koch's Postulates Applied to Microbial Pathogenicity

Stanley Falkow
Reviews of Infectious Diseases
Vol. 10, Supplement 2. Microbial Surfaces: Determinants of Virulence and Host Responsiveness (Jul. - Aug., 1988), pp. S274-S276
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4454582
Page Count: 3
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Molecular Koch's Postulates Applied to Microbial Pathogenicity
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Abstract

Microbial genetics and molecular cloning now permit us to routinely isolate specific genes from a variety of microbial pathogens. Obviously not all genes from pathogenic microorganisms play a role in pathogenicity or virulence. Just as Koch's postulates were formulated to identify the causal relationship between an organism and a specific disease, the notion is presented here that a form of molecular Koch's postulates is needed when examining the potential role of genes and their products in the pathogenesis of infection and disease.

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