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A Microbiological Comparison between Acute and Complicated Appendicitis
E. J. Baron, R. Bennion, J. Thompson, C. Strong, P. Summanen, M. McTeague and S. M. Finegold
Clinical Infectious Diseases
Vol. 14, No. 1 (Jan., 1992), pp. 227-231
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4456268
Page Count: 5
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Bacteria recovered from appendiceal specimens from 20 patients with acute appendicitis were compared with those recovered from 19 patients with complicated (gangrenous or perforative) appendicitis. Specimens of both peritoneal fluid and appendiceal tissue from patients with acute appendicitis yielded smaller numbers and fewer species of bacteria in culture than did specimens from patients with more complicated disease (2.3 strains per specimen for the former; 9.9 strains per specimen for the latter). Bacteria were recovered from all 13 cultures of specimens of appendiceal tissue and from 13 of 18 cultures of specimens of peritoneal fluid obtained from patients with gangrenous and perforative appendicitis; however, only eight of 17 cultures of appendiceal specimens and seven of 18 cultures of peritoneal fluid specimens from patients with acute appendicitis yielded bacteria. These findings suggest that some bacteria traverse the intact appendiceal wall prior to perforation and that progressive infection and subsequent tissue damage and necrosis allow larger numbers and varieties of bacteria to move through appendiceal wall tissue and into the peritoneal cavity.
Clinical Infectious Diseases © 1992 Oxford University Press