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Journal Article

NO Inhibitions: Antimicrobial Properties of Nitric Oxide

Mary Ann De Groote and Ferric C. Fang
Clinical Infectious Diseases
Vol. 21, Supplement 2. Abraham I. Braude Memorial Symposium on Infectious Diseases (Oct., 1995), pp. S162-S165
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4459007
Page Count: 4

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Topics: Oxides, Macrophages, Phagocytes, Mice, Infections, Antimicrobials, Endothelial cells, Nitrites, Killing, Nitrates
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NO Inhibitions: Antimicrobial Properties of Nitric Oxide
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Abstract

The past decade has witnessed a veritable explosion of interest in the simple molecule nitric oxide (NO) as a vasodilator, neurotransmitter, and antimicrobial agent. NO and other reactive nitrogen intermediates exhibit cytostatic or cytocidal activity against a remarkable breadth of pathogenic microorganisms. Mammalian cells, including human cells, produce nitric oxide both constitutively and inducibly in response to inflammatory stimuli. This review will provide a brief overview of current knowledge regarding the antimicrobial activity of NO and the possible importance of this activity in infection, particularly with regard to intracellular pathogens.

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