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Serum Therapy for Cryptococcal Meningitis

Morris A. Gordon and Arturo Casadevall
Clinical Infectious Diseases
Vol. 21, No. 6 (Dec., 1995), pp. 1477-1479
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4459110
Page Count: 3
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Serum Therapy for Cryptococcal Meningitis
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Abstract

Three patients were treated with combined amphotericin B and rabbit anticryptococcal antibody in the 1960s. Rabbit antibody was administered intravenously and was well tolerated. For each patient, administration of rabbit antibody resulted in the appearance of serum Cryptococcus neoformans agglutinins. For two patients the administration of rabbit antibody resulted in negative serum latex tests for cryptococcal antigen. This limited experience with adjunctive antibody therapy provides valuable precedents if antibody therapy is used again for treatment of human cryptococcosis.

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