Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Immunization of Healthy Adult Subjects in the United States with Inactivated Mycobacterium vaccae Administered in a Three-Dose Series

C. F. von Reyn, R. D. Arbeit, G. Yeaman, R. D. Waddell, B. J. Marsh, Paul Morin, John F. Modlin and Heinz G. Remold
Clinical Infectious Diseases
Vol. 24, No. 5 (May, 1997), pp. 843-848
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4459944
Page Count: 6
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
Immunization of Healthy Adult Subjects in the United States with Inactivated Mycobacterium vaccae Administered in a Three-Dose Series
Preview not available

Abstract

Heat-killed Mycobacterium vaccae vaccine was administered in a three-dose intradermal schedule to 10 healthy adult volunteers at 0, 2, and 10 months. Local and systemic side effects were monitored and vaccine site reactions were measured and photographed at visits 2 days, 14 days, and 2 months after each dose. Reactions to skin tests with purified protein derivative (PPD) and Mycobacterium avium sensitin (MAS) and titers of antibody to arabinose lipoarabinomannin were determined at baseline and after each dose of vaccine. Lymphocyte proliferation responses to MAS were determined after the final dose of vaccine. Immunization was safe and well tolerated, with maximal induration (range, 6-25 mm) at 2 days. PPD skin test conversions did not occur. Seven subjects completed the three-dose schedule; preexisting immunologic responses to mycobacteria were boosted in three, and a new response was elicited in one. M. vaccae vaccine is safe and induces measurable immunologic responses to mycobacterial antigens in some healthy adults.

Page Thumbnails

  • Thumbnail: Page 
843
    843
  • Thumbnail: Page 
844
    844
  • Thumbnail: Page 
845
    845
  • Thumbnail: Page 
846
    846
  • Thumbnail: Page 
847
    847
  • Thumbnail: Page 
848
    848