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Relative Neutralizing Activity in Polyspecific IgM, IgA, and IgG Preparations against Group A Streptococcal Superantigens
Anna Norrby-Teglund, Nahla Ihendyane, Rita Kansal, Hesham Basma, Malak Kotb, Jan Andersson and Lennart Hammarström
Clinical Infectious Diseases
Vol. 31, No. 5 (Nov., 2000), pp. 1175-1182
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4461406
Page Count: 8
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In this study we compared the ability of different immunoglobulin (Ig) preparations containing IgG, IgM, and/or IgA to neutralize the activity of streptococcal pyrogenic exotoxin A (SpeA) or culture supernatant from a clinical group A streptococcal isolate. All Ig preparations markedly inhibited the mitogenic and cytokine-inducing activity of SpeA and culture supernatant at concentrations of 0.05-0.5 mg/mL, and at 0.5 mg/mL, most caused 95-100% inhibition of both stimuli. A significantly higher (P ≤ .05) inhibition of SpeA was achieved by Pentaglobin (IgG, IgM, and IgA) and IgAbulin (IgA and IgG), as compared with pure IgG preparations. IgM- and IgA-enriched preparations had significantly higher inhibitory activity against SpeA than against culture supernatant, whereas the reverse was true for the IgG preparations (P ≤ .05). The data show that IgM and IgA are potent inhibitors of specific streptococcal superantigens. These findings may have implications for the optimization of immunotherapy in invasive streptococcal infections.
Clinical Infectious Diseases © 2000 Oxford University Press