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General Microbiology and in vitro Susceptibility of Anaerobes Isolated from Complicated Skin and Skin-Structure Infections in Patients Enrolled in a Comparative Trial of Ertapenem versus Piperacillin-Tazobactam

Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi Warren, Kerin L. Tyrrell and Richard M. Gesser
Clinical Infectious Diseases
Vol. 35, Supplement 1. 2001: An Anaerobe Odyssey: A Celebration of Dr. Sydney M. Finegold's 80th Birthday (Sep. 1, 2002), pp. S119-S125
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4462173
Page Count: 7
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General Microbiology and in vitro Susceptibility of Anaerobes Isolated from Complicated Skin and Skin-Structure Infections in Patients Enrolled in a Comparative Trial of Ertapenem versus Piperacillin-Tazobactam
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Abstract

In a recently completed study of once-a-day ertapenem versus piperacillin-tazobactam every 6 h in the treatment of complicated skin and skin-structure infections, 540 patients were randomized in a 1:1 ratio and assigned to 1 of 2 strata: those with a complicating underlying disease or all others. The most common infections in the study were deep soft-tissue abscess (18.9%), followed by diabetic lower extremity infection (18.1%); 7.0% of these were perineal cellulitis/abscess. With the exception of methicillin-resistant Staphylococcus aureus, almost all of the predominant aerobic pathogens were susceptible to both study drugs. Eighty-seven patients (16%) had ≥1 anaerobe identified in their baseline wound cultures, with a total of 232 anaerobic isolates. Of the 141 anaerobes tested for susceptibility, 97.2% were susceptible to ertapenem and 97.9% to piperacillin-tazobactam. Ertapenem had excellent in vitro activity against the most common aerobic pathogens and almost all anaerobes recovered from patients with infections of the skin and skin structures.

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