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Susceptibility of Antimicrobial-Resistant Urinary Escherichia coli Isolates to Fluoroquinolones and Nitrofurantoin
James A. Karlowsky, Clyde Thornsberry, Mark E. Jones and Daniel F. Sahm
Clinical Infectious Diseases
Vol. 36, No. 2 (Jan. 15, 2003), pp. 183-187
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4462250
Page Count: 5
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In vitro surveillance data from across the United States indicate that ∼10%-20% of urinary Escherichia coli isolates from female outpatients are resistant to trimethoprim-sulfamethoxazole (TMP-SMX). Alternative therapies for uncomplicated urinary tract infections in women include fluoroquinolones and nitrofurantoin, but the activities of these agents against TMP-SMX-resistant isolates are rarely reported. Among TMP-SMX-resistant urinary E. coli isolates tested in US laboratories from 1998 through 2001, 9.5% (5767 of 60,414) were resistant to ciprofloxacin and 1.9% (1214 of 63,817) were resistant to nitrofurantoin; 10.4% of ciprofloxacin-resistant isolates (683 of 6560) were resistant to nitrofurantoin. An association between resistance to fluoroquinolones and nitrofurantoin in E. coli has not been previously reported and warrants further study.
Clinical Infectious Diseases © 2003 Oxford University Press