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Reduced Testosterone Levels in Human Immunodeficiency Virus-Infected Women with Weight Loss and Low Weight

Jeannie S. Huang, Stephanie J. Wilkie, Sara Dolan, James H. Gallafent, Negar Aliabadi, Meghan P. Sullivan and Steven Grinspoon
Clinical Infectious Diseases
Vol. 36, No. 4 (Feb. 15, 2003), pp. 499-506
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4462339
Page Count: 8
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Reduced Testosterone Levels in Human Immunodeficiency Virus-Infected Women with Weight Loss and Low Weight
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Abstract

Risk factors for hypoandrogenemia among low-weight, human immunodeficiency virus (HIV)-infected patients are not known. Testosterone levels of 69 HIV-infected women with low weight and weight loss were compared with levels for 25 healthy, age- and body mass index-matched control subjects. HIV-infected subjects were of low weight, with a mean (± standard deviation) weight loss of -17.6% ± 9.7% from preillness maximum, and 42% of HIV-infected subjects had a body mass index of <20 kg/m². Forty-nine percent of the HIV-infected population versus 8% of the control population exhibited low free testosterone levels (P<.001). Among HIV-infected women, when we controlled for chronic hepatitis status, age, and time of blood sampling, weight loss of >10% of maximum weight was a significant predictor of low free testosterone levels. Free testosterone levels did not differ by drug class or antiretroviral regimen. In conclusion, decreased androgen levels are common among HIV-infected women reporting significant weight loss, independent of exposure to antiretroviral medications.

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