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Novel Antibiotic Combinations against Infections with Almost Completely Resistant Pseudomonas aeruginosa and Acinetobacter Species
James J. Rahal
Clinical Infectious Diseases
Vol. 43, Supplement 2. Serious Infections in the Intensive Care Unit: Pseudomonas aeruginosa and Acinetobacter baumanni (Sep. 1, 2006), pp. S95-S99
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4463904
Page Count: 5
You can always find the topics here!Topics: Antibiotics, Infections, Polymyxins, Pseudomonas aeruginosa, Acinetobacter baumannii, Acinetobacter, Aminoglycosides, Infectious diseases, Bacteremia, Pathogens
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For infections with antibiotic-susceptible strains of Pseudomonas aeruginosa, most studies have suggested that combination therapy, usually with a β-lactam antibiotic plus an aminoglycoside, is preferable for patients with bacteremia and neutropenia. Against infections with Pseudomonas aeruginosa or Acinetobacter baumannii isolates that are resistant to all antibiotics except the polymyxins, several novel antibiotic combinations demonstrate increased activity in vitro compared with that of any single agent. Whether these combinations yield outcomes that are improved over those seen with a polymyxin or other agent alone remains to be determined. However, against infections with species resistant to all antibiotics, including polymyxins, novel combinations are the only remaining therapeutic option.
Clinical Infectious Diseases © 2006 Oxford University Press