Access

You are not currently logged in.

Access JSTOR through your library or other institution:

login

Log in through your institution.

Journal Article

Novel Antibiotic Combinations against Infections with Almost Completely Resistant Pseudomonas aeruginosa and Acinetobacter Species

James J. Rahal
Clinical Infectious Diseases
Vol. 43, Supplement 2. Serious Infections in the Intensive Care Unit: Pseudomonas aeruginosa and Acinetobacter baumanni (Sep. 1, 2006), pp. S95-S99
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4463904
Page Count: 5
Were these topics helpful?
See something inaccurate? Let us know!

Select the topics that are inaccurate.

  • Download ($42.00)
  • Subscribe ($19.50)
  • Add to My Lists
  • Cite this Item
Novel Antibiotic Combinations against Infections with Almost Completely Resistant Pseudomonas aeruginosa and Acinetobacter Species
Preview not available

Abstract

For infections with antibiotic-susceptible strains of Pseudomonas aeruginosa, most studies have suggested that combination therapy, usually with a β-lactam antibiotic plus an aminoglycoside, is preferable for patients with bacteremia and neutropenia. Against infections with Pseudomonas aeruginosa or Acinetobacter baumannii isolates that are resistant to all antibiotics except the polymyxins, several novel antibiotic combinations demonstrate increased activity in vitro compared with that of any single agent. Whether these combinations yield outcomes that are improved over those seen with a polymyxin or other agent alone remains to be determined. However, against infections with species resistant to all antibiotics, including polymyxins, novel combinations are the only remaining therapeutic option.

Page Thumbnails

  • Thumbnail: Page 
S95
    S95
  • Thumbnail: Page 
S96
    S96
  • Thumbnail: Page 
S97
    S97
  • Thumbnail: Page 
S98
    S98
  • Thumbnail: Page 
S99
    S99