You are not currently logged in.
Access JSTOR through your library or other institution:
Overexpression of Fas/CD95 and Fas-Induced Apoptosis in a Patient with Idiopathic CD4⁺ T Lymphocytopenia
Pierre-Marie Roger, Ghislaine Bernard-Pomier, Evelyne Counillon, Jean-Philippe Breittmayer, Alain Bernard and Pierre Dellamonica
Clinical Infectious Diseases
Vol. 28, No. 5 (May, 1999), pp. 1012-1016
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4481800
Page Count: 5
You can always find the topics here!Topics: T lymphocytes, Apoptosis, Lymphopenia, Lymphocytes, B lymphocytes, Monoclonal antibodies, Blood, Antibodies, Natural killer cells, Fluorescence
Were these topics helpful?See something inaccurate? Let us know!
Select the topics that are inaccurate.
Preview not available
The mechanisms of apoptosis have become better understood, in part with the discovery of Fas/CD95. We report the case of a patient characterized by a decreased CD4⁺ T cell count and an overexpression of Fas/CD95 resulting in apoptosis. A 54-year-old man presented with disseminated Mycobacterium xenopi infection. Analysis showed CD4⁺ T lymphopenia. Tests for human immunodeficiency virus (HIV) types 1 and 2 were negative. We compared the patient with eight healthy controls and five HIV-infected patients in terms of the expression of Fas/CD95 and Fas-mediated apoptosis of peripheral T lymphocytes. The percent of CD95⁺ cells in lymphocytes was 98% for the patient, and the mean percent of CD95⁺ cells in lymphocytes ± SD for HIV-infected patients and healthy controls was 75% ± 16% and 36% ± 26%, respectively. The patient had a high level of spontaneous apoptosis, and apoptotic cells were all identified as being CD4⁺ T cells. Monoclonal antibodies to CD95 dramatically increased apoptosis of CD4⁺ T cells exclusively. CD4⁺ T lymphopenia observed in our patient correlated with an overexpression of Fas together with spontaneous and Fas-induced apoptosis.
Clinical Infectious Diseases © 1999 Oxford University Press