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Mucormycosis (Zygomycosis) in a Heart-Kidney Transplant Recipient: Recovery after Posaconazole Therapy
Angela Ma Tobón, Myrtha Arango, Darío Fernández and Angela Restrepo
Clinical Infectious Diseases
Vol. 36, No. 11 (Jun. 1, 2003), pp. 1488-1491
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4483542
Page Count: 4
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We describe the case of a diabetic patient who developed a severe invasive fungal infection due to Rhizopus species post-operatively after a dual heart/kidney transplantation with subsequent intensive immunosuppressive therapy. No improvement was noted with amphotericin B (deoxycholate) therapy, but salvage treatment with the new azole antifungal posaconazole (200 mg orally 4 times daily) resulted in dramatic clinical improvement as early as 1 week after the initiation of therapy that continued through 23 weeks of treatment, with marked clinical, mycological, and radiological improvements and no adverse events.
Clinical Infectious Diseases © 2003 Oxford University Press