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Pathobiology of H9N2 Avian Influenza Virus in Japanese Quail (Coturnix coturnixjaponica) ($Patobiolog\acute{i}a$ del virus de influenza aviar (H9N2) en codornices Japonesas (Coturnix coturnix japonica))

H. Nili, K. Asasi, H. Dadras and M. Ebrahimi
Avian Diseases
Vol. 51, No. 1, Supplement: Sixth International Symposium on Avian Influenza (Mar., 2007), pp. 390-392
Stable URL: http://www.jstor.org/stable/4493234
Page Count: 3
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Pathobiology of H9N2 Avian Influenza Virus in Japanese Quail (Coturnix coturnixjaponica) ($Patobiolog\acute{i}a$ del virus de influenza aviar (H9N2) en codornices Japonesas (Coturnix coturnix japonica))
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Abstract

Clinical signs, serologic response, viral contents of the trachea and intestine, and histopathological and ultrastructural changes of the tracheal epithelium of Japanese quail experimentally infected with field isolate of H9N2 avian influenza were studied. Vaccinated and unvaccinated quail were inoculated with 106.3 50% embryo infectious dose/bird of A/ chicken/Iran/SH-110/99 (H9N2) virus via nasal inoculation. Clinical signs such as depression, ruffled feathers, diarrhea, and nasal and eye discharges were observed 6 days postinfection (PI). No mortality was observed; however, there was reduction in feed and water consumption and egg production. However, the serologic response of vaccinated challenged and unvaccinated challenged birds was not significantly different. Unvaccinated challenged quail showed more severe histopathologic reaction in their lungs and trachea. Hyperemia, edema, infiltration of inflammatory cells, and deciliation and sloughing of the tracheal epithelium were observed. Ultrastructural study showed dilatation of endoplasmic reticulum and degeneration of Golgi apparatus and cilia of the tracheal lining cells of respiratory epithelium. /// Se estudiaron los signos $cl\acute{i}nicos$, la respuesta $serol\acute{o}gica$, el contenido de virus en la $tr\acute{a}quea$ e intestino, así como los cambios $histopatol\acute{o}gicos$ y ultraestructurales del epitelio de la $tr\acute{a}quea$ de codornices Japonesas infectadas experimentalmente con un aislamiento de campo H9N2 de influenza aviar. Codornices vacunadas y no vacunadas se inocularon por $v\acute{i}a$ nasal con 106.3 dosis infecciosa 50% del virus A/chicken/Iran/SH-110/99 (H9N2) por ave. Seis $d\acute{i}as$ posteriores a la $infecci\acute{o}n$, se observaron signos $cl\acute{i}nicos$ tales como $depresi\acute{o}n$, plumas erizadas, diarrea y descargas nasales y oculares. No se $obverv\acute{o}$ mortalidad, sin embargo, hubo una $reducci\acute{o}n$ del consumo de agua y alimento y de la $producci\acute{o}n$ de huevos. Sin embargo, la respuesta $serol\acute{o}gica$ de las ayes vacunadas y desafiadas y las ayes no vacunadas y desafiadas no $difiri\acute{o}$ significativamente. Las codornices no vacunadas y desafiadas mostraron reacciones $histopatol\acute{o}gicas$ más severas en sus pulmones y $tr\acute{a}queas$. Se $observ\acute{o}$ hiperemia, edema, $infiltraci\acute{o}n$ de $c\acute{e}lulas$ inflamatorias y $desciliaci\acute{o}n$ y desprendimiento del epitelio traqueal. $evaluaci\acute{o}n$ ultraestructural $demostr\acute{o}$ la $dilataci\acute{o}n$ del $ret\acute{i}culo$ $endoplasm\acute{a}tico$ y la $degeneraci\acute{o}n$ del aparato de Golgi, así como de los cilios de las celulas del borde del epitelio respiratorio.

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