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Factors Associated with Severe Impact of Lipodystrophy on the Quality of Life of Patients Infected with HIV-1

Jordi Blanch, Araceli Rousaud, Esteban Martínez, Elisa De Lazzari, Ana Milinkovic, Josep-Maria Peri, José-Luís Blanco, Jesús Jaen, Victor Navarro, Guillem Massana and Josep-Maria Gatell
Clinical Infectious Diseases
Vol. 38, No. 10 (May 15, 2004), pp. 1464-1470
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4529121
Page Count: 7
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Factors Associated with Severe Impact of Lipodystrophy on the Quality of Life of Patients Infected with HIV-1
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Abstract

A standardized questionnaire was used to assess the impact of lipodystrophy (LD) on quality of life (QoL). Eighty-four consecutive asymptomatic human immunodeficiency virus type 1 (HIV-1)-infected outpatients with clinical LD completed a modified version of the Dermatology Life Quality Index (DLQI) survey to measure the impact of body fat changes on their QoL. Body changes influenced dressing for 55 patients (65%), produced feelings of shame for 41 (49%), and disrupted sexual life for 23 (27%). There was a greater impact on the DLQI due to body changes among women, injection drug users, patients with abdominal or breast lipoaccumulation, and patients with a high number of non-LD side effects. Multivariate proportional odds model analysis showed that the severity of non-LD-associated side effects and the presence of breast lipoaccumulation were associated with impaired psychosocial functioning. Specific characteristics of patients, antiretroviral-based side effects, and breast lipoaccumulation exert a greater impact on QoL in HIV-1-infected patients with LD.

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