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The Search for a Predictor of CD4 Cell Count Continues: Total Lymphocyte Count Is Not a Substitute for CD4 Cell Count in the Management of HIV-Infected Individuals in a Resource-Limited Setting

N. O. Akinola, O. Olasode, I. A. Adediran, O. Onayemi, A. Murainah, O. Irinoye, A. A. Elujoba and M. A. Durosinmi
Clinical Infectious Diseases
Vol. 39, No. 4 (Aug. 15, 2004), pp. 579-581
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/4536687
Page Count: 3
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The Search for a Predictor of CD4 Cell Count Continues: Total Lymphocyte Count Is Not a Substitute for CD4 Cell Count in the Management of HIV-Infected Individuals in a Resource-Limited Setting
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Abstract

Total lymphocyte count (TLC) has been recommended as a substitute for CD4 cell count for the management of HIV-infected individuals living in resource-limited settings. To confirm this, 151 TLCs and CD4 cell counts were obtained from 109 patients who had not yet started treatment and analyzed. CD4 cell counts of <200 cells/mm³ were found in 42 cases (37.8%) with TLCs of ≥1200 cells/mm³. Thus, 1 in 3 individuals would have been deprived of needed treatment. Therefore, in this setting, TLC is not a reliable predictor of CD4 cell count in HIV-infected individuals.

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