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An Evaluation of the Kolmer Reiter Protein and Fluorescent Treponemal Antibody Tests
Cecil B. Tucker, George M. Cameron, Rufus L. Buchanan, Ann Dillon and John H. Grayson
Public Health Reports (1896-1970)
Vol. 77, No. 12 (Dec., 1962), pp. 1089-1094
Published by: Association of Schools of Public Health
Stable URL: http://www.jstor.org/stable/4591708
Page Count: 6
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A study of 842 blood specimens which gave reactions in a range of 1 to 4 dilutions with the VDRL tube test was undertaken to determine the relative sensitivity and specificity of the Kolmer Reiter protein (KRP) and the fluorescent treponemal antibody (FTA) tests as well as the significance of low titer VDRL serologic tests for syphilis. The FTA test showed high specificity and relatively high sensitivity when compared with the Treponema pallidum immobilization (TPI) test. The KRP test showed low sensitivity when compared with the TPI and FTA tests. For patients with unexplained low titer VDRL tests as well as for patients with no historical or clinical evidence of syphilis infection whose VDRL tests show high titers, the FTA test appears to be a reference test of choice. Approximately 10 percent of blood specimens yielding low titer VDRL tests represented biologic false positive reactions when based on the FTA tests in this study. The results of the study indicate a need for careful and complete evaluation of each patient with an unexplained low titer VDRL test.
Public Health Reports (1896-1970) © 1962 Association of Schools of Public Health