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Characterization of the Antibody Response to Acetone-Killed Typhoid Vaccine

Robert P. May, Jack A. Barnett and Jay P. Sanford
Public Health Reports (1896-1970)
Vol. 82, No. 3 (Mar., 1967), pp. 257-260
DOI: 10.2307/4592986
Stable URL: http://www.jstor.org/stable/4592986
Page Count: 4
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Characterization of the Antibody Response to Acetone-Killed Typhoid Vaccine
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Abstract

Clinical and experimental observations suggested that gamma G antibodies might provide more protection against infective organisms than gamma M antibodies. Acetone-killed typhoid vaccine has been shown to produce better protection than the heat-killed phenolized type. In an attempt to relate these two observations, 12 volunteers were immunized with acetone-killed typhoid vaccine to determine if gamma G anti-O antibodies would be formed rather than the gamma M anti-O antibodies that develop in response to heat-killed phenolized vaccine. Differences in the antibodies formed might account, it was believed, for differences in the protective capacity of the two types of vaccine. The antibody responses to injection of acetone-killed vaccine, however, were quantitatively and qualitatively similar to those observed after immunization with heat-killed phenolized vaccine.

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