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Incidence of Bacterial Meningitis in Asia Using Enhanced CSF Testing: Polymerase Chain Reaction, Latex Agglutination and Culture
W. A. Kennedy, S-J. Chang, K. Purdy, T. Le, P. E. Kilgore, J. S. Kim, D. D. Anh, P. L. T. Huong, B. Q. Dong, D. M. Tan, J. D. Clemens and J. I. Ward
Epidemiology and Infection
Vol. 135, No. 7 (Oct., 2007), pp. 1217-1226
Published by: Cambridge University Press
Stable URL: http://www.jstor.org/stable/4621185
Page Count: 10
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To enhance the detection of bacterial meningitis in an East Asian surveillance study, we employed cerebrospinal fluid (CSF) bacterial culture, latex agglutination (LA) and polymerase chain reaction-enzyme immunoassay (PCR-EIA) testing for Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae (Sp). The sensitivity and specificity of CSF PCR-EIA testing was compared to LA and culture. A meningitis case was defined by one positive result for any of the three tests. The sensitivity of H. influenzae CSF PCR-EIA, LA, and culture was 100 %, 40 % and 57‧5% respectively; and for Sp CSF PCR-EIA, LA and culture, the sensitivity was 100%, 58‧3 % and 66‧7 %, respectively. Hib and Sp specificity was 100 % by each method. CSF PCR-EIA was more sensitive than culture or LA for the detection of Hib and Sp meningitis cases increasing their incidence by 74 % and 50 % compared to culture respectively. CSF PCR-EIA should be included for the detection of bacterial meningitis in surveillance studies.
Epidemiology and Infection © 2007 Cambridge University Press