Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Incidence of Bacterial Meningitis in Asia Using Enhanced CSF Testing: Polymerase Chain Reaction, Latex Agglutination and Culture

W. A. Kennedy, S-J. Chang, K. Purdy, T. Le, P. E. Kilgore, J. S. Kim, D. D. Anh, P. L. T. Huong, B. Q. Dong, D. M. Tan, J. D. Clemens and J. I. Ward
Epidemiology and Infection
Vol. 135, No. 7 (Oct., 2007), pp. 1217-1226
Stable URL: http://www.jstor.org/stable/4621185
Page Count: 10
  • Read Online (Free)
  • Download ($49.00)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Incidence of Bacterial Meningitis in Asia Using Enhanced CSF Testing: Polymerase Chain Reaction, Latex Agglutination and Culture
Preview not available

Abstract

To enhance the detection of bacterial meningitis in an East Asian surveillance study, we employed cerebrospinal fluid (CSF) bacterial culture, latex agglutination (LA) and polymerase chain reaction-enzyme immunoassay (PCR-EIA) testing for Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae (Sp). The sensitivity and specificity of CSF PCR-EIA testing was compared to LA and culture. A meningitis case was defined by one positive result for any of the three tests. The sensitivity of H. influenzae CSF PCR-EIA, LA, and culture was 100 %, 40 % and 57‧5% respectively; and for Sp CSF PCR-EIA, LA and culture, the sensitivity was 100%, 58‧3 % and 66‧7 %, respectively. Hib and Sp specificity was 100 % by each method. CSF PCR-EIA was more sensitive than culture or LA for the detection of Hib and Sp meningitis cases increasing their incidence by 74 % and 50 % compared to culture respectively. CSF PCR-EIA should be included for the detection of bacterial meningitis in surveillance studies.

Page Thumbnails

  • Thumbnail: Page 
[1217]
    [1217]
  • Thumbnail: Page 
1218
    1218
  • Thumbnail: Page 
1219
    1219
  • Thumbnail: Page 
1220
    1220
  • Thumbnail: Page 
1221
    1221
  • Thumbnail: Page 
1222
    1222
  • Thumbnail: Page 
1223
    1223
  • Thumbnail: Page 
1224
    1224
  • Thumbnail: Page 
1225
    1225
  • Thumbnail: Page 
1226
    1226