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Endogenous E2F-1 Promotes Timely G0 Exit of Resting Mouse Embryo Fibroblasts
Zhiyan M. Wang, Hong Yang and David M. Livingston
Proceedings of the National Academy of Sciences of the United States of America
Vol. 95, No. 26 (Dec. 22, 1998), pp. 15583-15586
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/46421
Page Count: 4
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Much evidence strongly suggests a positive role for one or more E2F species in the control of exit from G0/G1. Results described here provide direct evidence that endogenous E2F-1, as predicted, contributes to progression from G0 to S. By contrast, cycling cells lacking an intact E2F-1 gene demonstrated normal cell cycle distribution. Therefore, E2F-1 exerts a unique function leading to timely G0 exit of resting cultured primary cells, while at the same time being unnecessary for normal G1 to S phase progression of cycling cells.
Proceedings of the National Academy of Sciences of the United States of America © 1998 National Academy of Sciences