Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Endogenous E2F-1 Promotes Timely G0 Exit of Resting Mouse Embryo Fibroblasts

Zhiyan M. Wang, Hong Yang and David M. Livingston
Proceedings of the National Academy of Sciences of the United States of America
Vol. 95, No. 26 (Dec. 22, 1998), pp. 15583-15586
Stable URL: http://www.jstor.org/stable/46421
Page Count: 4
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Endogenous E2F-1 Promotes Timely G0 Exit of Resting Mouse Embryo Fibroblasts
Preview not available

Abstract

Much evidence strongly suggests a positive role for one or more E2F species in the control of exit from G0/G1. Results described here provide direct evidence that endogenous E2F-1, as predicted, contributes to progression from G0 to S. By contrast, cycling cells lacking an intact E2F-1 gene demonstrated normal cell cycle distribution. Therefore, E2F-1 exerts a unique function leading to timely G0 exit of resting cultured primary cells, while at the same time being unnecessary for normal G1 to S phase progression of cycling cells.

Page Thumbnails

  • Thumbnail: Page 
15583
    15583
  • Thumbnail: Page 
15584
    15584
  • Thumbnail: Page 
15585
    15585
  • Thumbnail: Page 
15586
    15586