Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Impaired Growth and Fertility of cAMP-Specific Phosphodiesterase PDE4D-Deficient Mice

S.-L. Catherine Jin, Francois J. Richard, Wie-Peng Kuo, A. Joseph D'Ercole and Marco Conti
Proceedings of the National Academy of Sciences of the United States of America
Vol. 96, No. 21 (Oct. 12, 1999), pp. 11998-12003
Stable URL: http://www.jstor.org/stable/48924
Page Count: 6
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Impaired Growth and Fertility of cAMP-Specific Phosphodiesterase PDE4D-Deficient Mice
Preview not available

Abstract

In eukaryotic cells, the inactivation of the cyclic nucleotide signal depends on a complex array of cyclic nucleotide phosphodiesterases (PDEs). Although it has been established that multiple PDE isoenzymes with distinct catalytic properties and regulations coexist in the same cell, the physiological significance of this remarkable complexity is poorly understood. To examine the role of a PDE in cAMP signaling in vivo, we have inactivated the type 4 cAMP-specific PDE (PDE4D) gene, a mammalian homologue of the Drosophila dunce. This isoenzyme is involved in feedback regulation of cAMP levels. Mice deficient in PDE4D exhibit delayed growth as well as reduced viability and female fertility. The decrease in fertility of the null female is caused by impaired ovulation and diminished sensitivity of the granulosa cells to gonadotropins. These pleiotropic phenotypes demonstrate that PDE4D plays a critical role in cAMP signaling and that the activity of this isoenzyme is required for the regulation of growth and fertility.

Page Thumbnails

  • Thumbnail: Page 
11998
    11998
  • Thumbnail: Page 
11999
    11999
  • Thumbnail: Page 
12000
    12000
  • Thumbnail: Page 
12001
    12001
  • Thumbnail: Page 
12002
    12002
  • Thumbnail: Page 
12003
    12003