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Impaired Growth and Fertility of cAMP-Specific Phosphodiesterase PDE4D-Deficient Mice
S.-L. Catherine Jin, Francois J. Richard, Wie-Peng Kuo, A. Joseph D'Ercole and Marco Conti
Proceedings of the National Academy of Sciences of the United States of America
Vol. 96, No. 21 (Oct. 12, 1999), pp. 11998-12003
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/48924
Page Count: 6
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In eukaryotic cells, the inactivation of the cyclic nucleotide signal depends on a complex array of cyclic nucleotide phosphodiesterases (PDEs). Although it has been established that multiple PDE isoenzymes with distinct catalytic properties and regulations coexist in the same cell, the physiological significance of this remarkable complexity is poorly understood. To examine the role of a PDE in cAMP signaling in vivo, we have inactivated the type 4 cAMP-specific PDE (PDE4D) gene, a mammalian homologue of the Drosophila dunce. This isoenzyme is involved in feedback regulation of cAMP levels. Mice deficient in PDE4D exhibit delayed growth as well as reduced viability and female fertility. The decrease in fertility of the null female is caused by impaired ovulation and diminished sensitivity of the granulosa cells to gonadotropins. These pleiotropic phenotypes demonstrate that PDE4D plays a critical role in cAMP signaling and that the activity of this isoenzyme is required for the regulation of growth and fertility.
Proceedings of the National Academy of Sciences of the United States of America © 1999 National Academy of Sciences