You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Genotype-Environment Interactions and the Estimation of the Genomic Mutation Rate in Drosophila melanogaster
Alexey S. Kondrashov and David Houle
Proceedings: Biological Sciences
Vol. 258, No. 1353 (Dec. 22, 1994), pp. 221-227
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/50084
Page Count: 7
You can always find the topics here!Topics: Drosophila, Genotypes, Genetic mutation, Genetics, Productivity, Bottles, Mathematical constants, Female animals, Sustainable development, Fall lines
Were these topics helpful?See something inaccurate? Let us know!
Select the topics that are inaccurate.
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
We have studied the relative fitnesses of three genotypes of Drosophila melanogaster in 50 environments. Two genotypes, the MA lines, had accumulated mutations in the absence of natural selection over 62 generations. The third was a related strain where selection had continued to act. The environments differed in three factors: parental density, dilution of the medium, and the temperature regime and medium composition. Our measure of fitness assessed fecundity and viability relative to a reference genotype. Both MA lines always had lower fitnesses than the selected line, but the difference increased dramatically with dilution of the medium and, especially, crowding. Under the most severe conditions, the performance of the MA lines approached 0. This increased difference in harsh conditions may be caused both by a uniform increase in the magnitude of deleterious effects of all mutations and by the exposure of mutations which are essentially neutral under benign conditions. If the second cause is important, previous experiments are likely to have underestimated the genomic deleterious mutation rate in Drosophila melanogaster more than previously thought.
Proceedings: Biological Sciences © 1994 Royal Society