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Proteins with SH2 and SH3 Domains Couple Receptor Tyrosine Kinases to Intracellular Signalling Pathways

Tony Pawson, Paul Olivier, Maria Rozakis-Adcock, Jane McGlade and Mark Henkemeyer
Philosophical Transactions: Biological Sciences
Vol. 340, No. 1293, Signalling Mechanisms Involved in Control of Cell Growth (Jun. 29, 1993), pp. 279-285
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/55872
Page Count: 7
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Proteins with SH2 and SH3 Domains Couple Receptor Tyrosine Kinases to Intracellular Signalling Pathways
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Abstract

The targets of receptor protein-tyrosine kinases are characterized by Src homology 2 (SH2) domains, that mediate specific interactions with receptor autophosphorylation sites. SH2-mediated interactions are important for the activation of biochemical signalling pathways in cells stimulated with growth factors. A distinct protein module, the SH3 domain, is frequently found in polypeptides that contain SH2 domains, and is also implicated in controlling protein-protein interactions in signal transduction. Evidence suggesting that SH2 and SH3 domains act synergistically in stimulation of the Ras pathway is discussed.

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