Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Microsatellite and Trinucleotide-Repeat Evolution: Evidence for Mutational Bias and Different Rates of Evolution in Different Lineages

David C. Rubinsztein, Bill Amos and Gillian Cooper
Philosophical Transactions: Biological Sciences
Vol. 354, No. 1386, Glutamine Repeats and Neurodegenerative Diseases: Molecular Aspects (Jun. 29, 1999), pp. 1095-1099
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/56991
Page Count: 5
  • Read Online (Free)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Microsatellite and Trinucleotide-Repeat Evolution: Evidence for Mutational Bias and Different Rates of Evolution in Different Lineages
Preview not available

Abstract

Microsatellites are stretches of repetitive DNA, where individual repeat units comprise one to six bases. These sequences are often highly polymorphic with respect to repeat number and include trinucleotide repeats, which are abnormally expanded in a number of diseases. It has been widely assumed that microsatellite loci are as likely to gain and lose repeats when they mutate. In this review, we present population genetic and empirical data arguing that microsatellites, including normal alleles at trinucleotide-repeat disease loci, are more likely to expand in length when they mutate. In addition, our experiments suggest that the rates of expansion of such sequences differ in related species.

Page Thumbnails

  • Thumbnail: Page 
1095
    1095
  • Thumbnail: Page 
1096
    1096
  • Thumbnail: Page 
1097
    1097
  • Thumbnail: Page 
1098
    1098
  • Thumbnail: Page 
1099
    1099