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Immunochemistry of the Capsular Polysaccharide of an Acinetobacter

Michael Heidelberger, Amalendu Das and Elliot Juni
Proceedings of the National Academy of Sciences of the United States of America
Vol. 63, No. 1 (May 15, 1969), pp. 47-50
Stable URL: http://www.jstor.org/stable/59217
Page Count: 4
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Immunochemistry of the Capsular Polysaccharide of an Acinetobacter
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Abstract

The capsular polysaccharide of a strain, BD4, of Acinetobacter calco-aceticus (A.c-a), composed of L-rhamnose and D-glucose, 4:1, precipitates all streptococcal group B antisera tested, as well as streptococcal group G antisera and antipneumococcal (Pn) type XXIII serum. Nonreducing end groups of L-rhamnose, known to be major determinants of the antigens giving rise to these antisera, are thus identified in A.c-a, which also precipitates anti-Pn VI sera. Both the rhamnose and glucose in the capsular polysaccharide (S) of Pn VI are linked 1,3-, as is the rhamnose in Pn S II, which also precipitates anti-Pn VI because of this linkage. A.c-a and S II precipitate the same fraction of anti-Pn VI, identifying a second portion of the rhamnose of A.c-a as 1,3-linked. This is confirmed by the stability of a portion of the rhamnose on oxidation of A.c-a with periodate, and 1,3-linked glucose or a periodate-stable branch point is also indicated in the same way. Two features of the fine structure of A.c-a have thus been established and a third indicated.

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