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Stimulation of Anterior Pituitary Adenyl cyclase activity and adenosine 3′:5′-Cyclic phosphate by Hypothalamic Extract and Prostaglandin E1
Uriel Zor, Toshio Kaneko, Herman P. G. Schneider, Samuel M. McCann, Irene P. Lowe, Gail Bloom, Barbara Borland and James B. Field
Proceedings of the National Academy of Sciences of the United States of America
Vol. 63, No. 3 (Jul. 15, 1969), pp. 918-925
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/59437
Page Count: 8
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Hypothalamic extract, containing the releasing factors for anterior pituitary hormones, within minutes stimulated adenyl cyclase activity and adenosine 3′:5′-cyclic phosphate (cyAMP) concentrations in rat anterior pituitary in vitro. Cerebral cortical extract was ineffective and hypothalamic extract had no effect on these parameters in posterior pituitary or thyroid. Prostaglandin E1 also increased adenyl cyclase activity and cyAMP levels in anterior pituitary tissue. Although NaF augmented adenyl cyclase activity, it did not elevate cyAMP. Epinephrine, norepinephrine, histamine, serotonin, dopamine, and vasopressin did not increase either adenyl cyclase or cyAMP. The increased adenyl cyclase and cyAMP produced by hypothalamic extract was associated with greater luteinizing hormone release from anterior pituitary in vitro.
Proceedings of the National Academy of Sciences of the United States of America © 1969 National Academy of Sciences