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Stimulation of Anterior Pituitary Adenyl cyclase activity and adenosine 3:5-Cyclic phosphate by Hypothalamic Extract and Prostaglandin E1

Uriel Zor, Toshio Kaneko, Herman P. G. Schneider, Samuel M. McCann, Irene P. Lowe, Gail Bloom, Barbara Borland and James B. Field
Proceedings of the National Academy of Sciences of the United States of America
Vol. 63, No. 3 (Jul. 15, 1969), pp. 918-925
Stable URL: http://www.jstor.org/stable/59437
Page Count: 8
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Stimulation of Anterior Pituitary Adenyl cyclase activity and adenosine 3′:5′-Cyclic phosphate by Hypothalamic Extract and Prostaglandin E1
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Abstract

Hypothalamic extract, containing the releasing factors for anterior pituitary hormones, within minutes stimulated adenyl cyclase activity and adenosine 3:5-cyclic phosphate (cyAMP) concentrations in rat anterior pituitary in vitro. Cerebral cortical extract was ineffective and hypothalamic extract had no effect on these parameters in posterior pituitary or thyroid. Prostaglandin E1 also increased adenyl cyclase activity and cyAMP levels in anterior pituitary tissue. Although NaF augmented adenyl cyclase activity, it did not elevate cyAMP. Epinephrine, norepinephrine, histamine, serotonin, dopamine, and vasopressin did not increase either adenyl cyclase or cyAMP. The increased adenyl cyclase and cyAMP produced by hypothalamic extract was associated with greater luteinizing hormone release from anterior pituitary in vitro.

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