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Increase in Rat Brain Tyrosine Hydroxylase Activity Produced by Electroconvulsive Shock
Jose M. Musacchio, Louis Julou, Seymour S. Kety and Jacques Glowinski
Proceedings of the National Academy of Sciences of the United States of America
Vol. 63, No. 4 (Aug. 15, 1969), pp. 1117-1119
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/59468
Page Count: 3
You can always find the topics here!Topics: Brain, Electroconvulsive therapy, Norepinephrine, Brain stem, Enzymes, Enzyme activity, Mesencephalon, Hypothalamus, Quaternary ammonium compounds, Sulfates
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A sustained increase in the turnover of norepinephrine coupled with an increased concentration of that amine has, in a previous study, been observed in the brains of rats exposed to electroconvulsive shock twice daily for one week. The phenomenon has been further examined by studying the effects of a similar regimen of electroconvulsive shock upon tyrosine hydroxylase in the brain, since that enzyme appears to be rate-limiting in norepinephrine synthesis. A small (15%) but significant increase in the whole brain enzyme activity was found in the electroshock-treated animals. A significant increase of tyrosine hydroxylase activity was found in the brainstem (24%) and cortex (20%) of such animals.
Proceedings of the National Academy of Sciences of the United States of America © 1969 National Academy of Sciences