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Organic Anion-Binding Protein in Rat Liver: Drug Induction and its Physiologic Consequence

Humberto Reyes, A. Jonathan Levi, Zenaida Gatmaitan and Irwin M. Arias
Proceedings of the National Academy of Sciences of the United States of America
Vol. 64, No. 1 (Sep. 15, 1969), pp. 168-170
Stable URL: http://www.jstor.org/stable/59598
Page Count: 3
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Organic Anion-Binding Protein in Rat Liver: Drug Induction and its Physiologic Consequence
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Abstract

The administration of phenobarbital to rats enhanced hepatic uptake of an organic anion, bromsulphalein, in vivo and simultaneously increased the amount of Y, a hepatic cytoplasmic organic anion-binding protein. This study supports the postulate that Y is a major determinant in the selective hepatic uptake of certain organic anions from plasma. Induction of Y may contribute to the enhanced hepatic uptake and metabolism of various organic anions (drugs, hormones, etc.) produced by phenobarbital and other agents.

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