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The Mechanism of Viral Carcinogenesis by DNA Mammalian Viruses, VI. A New Class of Virus-Specific RNA Molecules in Cells Transformed by Group C Human Adenoviruses
Kei Fujinaga, Magdalena Pina and Maurice Green
Proceedings of the National Academy of Sciences of the United States of America
Vol. 64, No. 1 (Sep. 15, 1969), pp. 255-262
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/59611
Page Count: 8
You can always find the topics here!Topics: RNA, DNA, Viruses, Embryonic cells, Adenoviruses, Hybridity, Viral DNA, Neoplastic cell transformation, Molecules, Nucleotide sequences
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A new class of virus-specific RNA molecules was found in cells transformed by group C human adenovirus types 2, 5, and 6. RNA isolated from virus-free rat embryo cells transformed by adenovirus 2, 5, and 6 hybridized with all group C adenovirus DNA's (adenovirus 1, 2, 5, and 6) equally well, but not appreciably with group A and B adenovirus DNA's. Most likely no viral genes common to group A, B, and C adenoviruses are transcribed in adenovirus-transformed cells. Group C adenoviruses are closely related since they share 83 to 93 per cent of their base sequences as shown by DNA-DNA homology measurements. Group C DNA's share only 10 to 26 per cent of their base sequences with group A and B DNA's. Moreover, the shared sequences are not transcribed detectably in adenovirus transformed cells. Virus-specific RNA isolated from group C transformed cells contains 49 to 51 per cent G + C, but viral DNA's possess a 7 to 9 per cent higher G + C content. These differences suggest that only a portion of the viral genome with an average G + C content of 49 to 51 per cent is transcribed in group C adenovirus transformed cells.
Proceedings of the National Academy of Sciences of the United States of America © 1969 National Academy of Sciences