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Structure of the Peptidoglycan of Bacterial Spores: Occurrence of the Lactam of Muramic Acid
A. D. Warth and J. L. Strominger
Proceedings of the National Academy of Sciences of the United States of America
Vol. 64, No. 2 (Oct. 15, 1969), pp. 528-535
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/59780
Page Count: 8
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Six major oligosaccharides were released from the peptidoglycan of spores of Bacillus subtilis by lysozyme treatment. They were isolated and characterized as a disaccharide, tetrasaccharide, and hexasaccharide composed of equal amounts of muramic acid and glucosamine and containing two, three, and four acetyl groups, respectively. Three of the compounds were substituted by a single L-alanine residue, and the other three by a single tetrapeptide substituent on the acetylmuramic acid residue at the reducing end of each compound. The other muramic acid residue in the tetrasaccharides (and two of the three in the hexasaccharides) were shown to be present as muramic lactams, a sugar not previously found in nature and, hence, a unique spore constituent. Other features of the structure of spore peptidoglycan are discussed.
Proceedings of the National Academy of Sciences of the United States of America © 1969 National Academy of Sciences