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Studies on the Formation of Transfer Ribonucleic Acid-Ribosome Complexes, XI. Antibiotic Effects on Phenylalanyl-Oligonucleotide Binding to Ribosomes

Sidney Pestka
Proceedings of the National Academy of Sciences of the United States of America
Vol. 64, No. 2 (Oct. 15, 1969), pp. 709-714
Stable URL: http://www.jstor.org/stable/59806
Page Count: 6
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Studies on the Formation of Transfer Ribonucleic Acid-Ribosome Complexes, XI. Antibiotic Effects on Phenylalanyl-Oligonucleotide Binding to Ribosomes
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Abstract

The effect of antibiotics on the binding of phenylalanyl-oligonucleotide to ribosomes has been examined. The results show that many classes of antibiotics can interfere with binding of the aminoacyl-oligonucleotide terminus of tRNA to ribosomes: chloramphenicol, sparsomycin, D-WIN-5094, vernamycin A, PA114A, streptogramin, amicetin, gougerotin, tylosin, and spiramycin III. The results are consistent with the hypothesis that these antibiotics inhibit protein synthesis by interfering with the binding of the aminoacyl-end of aminoacyl-tRNA to ribosomes.

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