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A Variable Region Subclass of Heavy Chains Common to Immunoglobulins G, A, and M and Characterized by an Unblocked Amino-Terminal Residue

A. C. Wang, J. R. L. Pink, H. H. Fudenberg and J. Ohms
Proceedings of the National Academy of Sciences of the United States of America
Vol. 66, No. 3 (Jul. 15, 1970), pp. 657-663
Stable URL: http://www.jstor.org/stable/60224
Page Count: 7
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
A Variable Region Subclass of Heavy Chains Common to Immunoglobulins G, A, and M and Characterized by an Unblocked Amino-Terminal Residue
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Abstract

Heavy chains of IgG, IgA, and IgM classes of human immunoglobulins were compared by N-terminal residue determination and partial amino acid sequence analysis. A third subclass of the variable region of heavy chains was observed; an unblocked glutamic acid as the N-terminal residue is characteristic of this subclass. Our results indicated that the heavy chain variable region subclasses are not class specific, and that a given heavy chain variable region may be found in association with constant regions for μ -chains, α -chains, or γ -chains of various subclasses.

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