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Regulation of Methionine Biosynthesis in Escherichia coli: Mapping of the metJ Locus and Properties of a metJ+/metJ- Diploid
Ching-Hsiang Su and Ronald C. Greene
Proceedings of the National Academy of Sciences of the United States of America
Vol. 68, No. 2 (Feb., 1971), pp. 367-371
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/60381
Page Count: 5
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MetJ- mutants of Escherichia coli have elevated nonrepressible levels of the enzymes of methionine biosynthesis and S-adenosylmethionine synthetase (ATP:L-methionine S-adenosyltransferase, EC 22.214.171.124). In E. coli, as in Salmonella typhimurium, the metJ locus is close to metB (95% cotransduction of metB and metJ markers), but in E. coli the order is reversed, with metJ mapping clockwise to metB. A stable merodiploid, heterozygous for metJ, is subject to repression by methionine. Thus, metJ functions via a diffusible product. MetJ could either be a regulatory locus or could code for an enzyme required for the synthesis of a methionine metabolite that functions in the control system.
Proceedings of the National Academy of Sciences of the United States of America © 1971 National Academy of Sciences