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Synthesis of Epstein-Barr Virus after Activation of the Viral Genome in a "Virus-Negative" Human Lymphoblastoid Cell (Raji) Made Resistant to 5-bromodeoxyuridine
Berge Hampar, Jeffery G. Derge, Lidia M. Martos and John L. Walker
Proceedings of the National Academy of Sciences of the United States of America
Vol. 69, No. 1 (Jan., 1972), pp. 78-82
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/60984
Page Count: 5
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The Raji line of human lymphoblastoid cells, which does not show expression of Epstein-Barr virus, was made resistant to 5-bromodeoxyuridine. Within several weeks after removal of the drug, Epstein-Barr virus particles were detected in the cells. The sequence of virus appearance in the 5-bromodeoxyuridine-resistant cells indicated drug-induced activation of a repressed Epstein-Barr virus genome.
Proceedings of the National Academy of Sciences of the United States of America © 1972 National Academy of Sciences