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Inhibition of Influenza Virus Replication by α -amanitin: Mode of Action
B. W. J. Mahy, N. D. Hastie and Sylvia J. Armstrong
Proceedings of the National Academy of Sciences of the United States of America
Vol. 69, No. 6 (Jun., 1972), pp. 1421-1424
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/61403
Page Count: 4
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The replication of influenza virus in chick embryo fibroblast cells is inhibited by α -amanitin added during the first 2 hr of infection at concentrations similar to those required to inhibit cellular DNA-dependent RNA polymerase form II in vivo. Of two periods of increased RNA synthesis observed in cells infected with influenza virus, only the first, occurring from 0 to 2 hr after infection, is sensitive to α -amanitin. During this early period, there is a stimulation of the activity of DNA-dependent RNA polymerase II of nuclei isolated from infected cells. The data suggest that DNA transcription mediated by polymerase II is essential for influenza virus replication.
Proceedings of the National Academy of Sciences of the United States of America © 1972 National Academy of Sciences