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Inhibition of Influenza Virus Replication by α -amanitin: Mode of Action

B. W. J. Mahy, N. D. Hastie and Sylvia J. Armstrong
Proceedings of the National Academy of Sciences of the United States of America
Vol. 69, No. 6 (Jun., 1972), pp. 1421-1424
Stable URL: http://www.jstor.org/stable/61403
Page Count: 4
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Inhibition of Influenza Virus Replication by α -amanitin: Mode of Action
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Abstract

The replication of influenza virus in chick embryo fibroblast cells is inhibited by α -amanitin added during the first 2 hr of infection at concentrations similar to those required to inhibit cellular DNA-dependent RNA polymerase form II in vivo. Of two periods of increased RNA synthesis observed in cells infected with influenza virus, only the first, occurring from 0 to 2 hr after infection, is sensitive to α -amanitin. During this early period, there is a stimulation of the activity of DNA-dependent RNA polymerase II of nuclei isolated from infected cells. The data suggest that DNA transcription mediated by polymerase II is essential for influenza virus replication.

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