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Control of the Rat Pineal Gland by Light Spectra
Daniel P. Cardinali, Frances Larin and Richard J. Wurtman
Proceedings of the National Academy of Sciences of the United States of America
Vol. 69, No. 8 (Aug., 1972), pp. 2003-2005
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/61460
Page Count: 3
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Control of pineal hydroxyindole-O-methyl transferase (S-adenosylmethionine:N-acetylserotonin-O-methyl transferase; EC 22.214.171.124) by light spectra was determined by placing groups of rats previously housed in continuous darkness under one of seven light sources for 96 hr; rats were exposed to the same intensity of irradiation. Activity of the enzyme was lowest in rats maintained under green light (λ peak = 530 nm); blue and yellow light were somewhat less effective; red and ultraviolet light did not significantly lower the enzyme activity. The suppression of pineal hydroxyindole-O-methyl transferase by full-spectrum light sources could be correlated with the proportions of their spectral outputs in the blue-green-yellow range. These observations suggest that the retinal photopigment that mediates pineal responses to light in rats is rhodopsin or another compound with similar absorption properties.
Proceedings of the National Academy of Sciences of the United States of America © 1972 National Academy of Sciences