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Induction and Superinduction of Serotonin N-acetyltransferase by Adrenergic Drugs and Denervation in Rat Pineal Organ
Takeo Deguchi and Julius Axelrod
Proceedings of the National Academy of Sciences of the United States of America
Vol. 69, No. 8 (Aug., 1972), pp. 2208-2211
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/61506
Page Count: 4
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Activity of serotonin N-acetyltransferase (EC 188.8.131.52) in rat pineal organ is rapidly and markedly elevated in vivo after administration of β -(3,4-dihydroxyphenyl)-L-alanine (L-DOPA), norepinephrine, epinephrine, isoproterenol, monoamine oxidase inhibitors, or theophylline. Serotonin or 5-hydroxytryptophan has no effect on the increase in activity of this enzyme. Inhibitors of protein synthesis or propranolol, a β -adrenergic blocking agent completely inhibit(s) the increase in activity of serotonin N-acetyltransferase induced by drugs, indicating that new enzyme molecules are formed via stimulation of β -receptors of pineal cells and adenosine 3′:5′-cyclic monophosphate. When rat pineal organ is denervated by ganglionectomy, β -(3,4-dihydroxyphenyl)-L-alanine induces much more serotonin N-acetyltransferase than in the innervated gland. This superinduction by denervation appears to be due to changes of the postsynaptic site, probably the β -adrenergic receptor on the pineal cell.
Proceedings of the National Academy of Sciences of the United States of America © 1972 National Academy of Sciences