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Journal Article

Mammalian Cells with Altered Forms of RNA Polymerase II

V. L. Chan, G. F. Whitmore and Louis Siminovitch
Proceedings of the National Academy of Sciences of the United States of America
Vol. 69, No. 11 (Nov., 1972), pp. 3119-3123
Stable URL: http://www.jstor.org/stable/61549
Page Count: 5

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Topics: CHO cells, RNA, Enzymes, DNA, Cells, Cell culture techniques, Cell growth, Somatic cells, Cell lines, Ovaries
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Mammalian Cells with Altered Forms of RNA Polymerase II
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Abstract

Mutants of Chinese hamster ovary cells that are resistant to α -amanitin can be isolated. At least some of these mutants contain an altered form of DNA-dependent RNA polymerase II, as indicated by its resistance to α -amanitin. These results indicate that mutation to α -amanitin resistance involves a change of a structural gene.

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