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Proposed Tertiary Structure for the Hypothalamic Thyrotropin-Releasing Factor

Douglas E. Blagdon, Jean Rivier and Murray Goodman
Proceedings of the National Academy of Sciences of the United States of America
Vol. 70, No. 4 (Apr., 1973), pp. 1166-1168
Stable URL: http://www.jstor.org/stable/62447
Page Count: 3
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Proposed Tertiary Structure for the Hypothalamic Thyrotropin-Releasing Factor
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Abstract

Semiempirical energy calculations were performed to determine the conformation of the thyrotropin-releasing factor, L-pyroglutamyl-L-histidyl-L-prolineamide. Our results strongly suggest a ``hairpin turn'' conformation stabilized by two specific hydrogen bonds. Experimental support for this structure was obtained from proton magnetic resonance by use of chemical shifts and coupling constants with the implied dihedral angles.

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