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The Acquisition of Specificity in Cutaneous Sensory Neurons: A Reconsideration of the Integumental Specification Hypothesis
Joseph H. Sklar and R. K. Hunt
Proceedings of the National Academy of Sciences of the United States of America
Vol. 70, No. 12, Part I (Dec., 1973), pp. 3684-3688
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/62913
Page Count: 5
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Neuronal specificity in cutaneous sensory nerve cells has been postulated to arise from ``inductive interactions'' between the cell's randomly outgrown peripheral neurite and local biochemical markers in the skin. Here we apply this integumental specification hypothesis to data recently obtained on the wiping-reflex behavior of frogs skin-grafted at various times during larval life. Deductions are generated about the developmental time course of the postulated nerve-skin interactions and two predictions are formulated and tested. Because the results of serial skin rotation experiments contradict the predictions, we conlude that the currently held hypothesis must be seriously questioned.
Proceedings of the National Academy of Sciences of the United States of America © 1973 National Academy of Sciences