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A Calcium-Dependent Mechanism for Synapse and Nerve Cell Membrane Modulation

Holger Hyden
Proceedings of the National Academy of Sciences of the United States of America
Vol. 71, No. 8 (Aug., 1974), pp. 2965-2968
Stable URL: http://www.jstor.org/stable/63169
Page Count: 4
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
A Calcium-Dependent Mechanism for Synapse and Nerve Cell Membrane Modulation
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Abstract

A theory is presented according to which the neuronal membrane and synapses are influenced by membrane-bound S100 protein and a membrane-associated network of actin-like, 20- angstrom -diameter, coiled filaments and the competition by both proteins for Ca2+. The discussion is based on observations made with fluorescein- and peroxidase-conjugated antiserum against S100 protein on isolated nerve cells. A small part of the S100 protein is membrane-bound in a polar localization that develops postnatally. The competition for Ca2+ can influence the state of the network filaments which uncoil on binding Ca2+ and affect differently the conformational state of synapses and membrane depending on the S100 protein content.

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