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Location of the Spike Glycoproteins in the Semliki Forest Virus Membrane

Henrik Garoff and Kai Simons
Proceedings of the National Academy of Sciences of the United States of America
Vol. 71, No. 10 (Oct., 1974), pp. 3988-3992
Stable URL: http://www.jstor.org/stable/64111
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Location of the Spike Glycoproteins in the Semliki Forest Virus Membrane
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Abstract

Labeling experiments with formyl-[35 S]methionyl sulfone methylphosphate and crosslinking studies with dimethylsuberimidate suggest that the spike glycoproteins of Semliki Forest virus extend through the viral membrane into close contact with the nucleocapsid. Based on this finding, we present a mechanism for the formation of virus-specific patches in the host cell plasma membrane during virus assembly.

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