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Isolation of a Polypeptide that has Lymphocyte-Differentiating Properties and is Probably Represented Universally in Living Cells

Gideon Goldstein, Margrit Scheid, Ulrich Hammerling, Edward A. Boyse, David H. Schlesinger and Hugh D. Niall
Proceedings of the National Academy of Sciences of the United States of America
Vol. 72, No. 1 (Jan., 1975), pp. 11-15
Stable URL: http://www.jstor.org/stable/64264
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Isolation of a Polypeptide that has Lymphocyte-Differentiating Properties and is Probably Represented Universally in Living Cells
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Abstract

A polypeptide of 8500 molecular weight is described that induces the differentiation of T (thymus-derived) cell and B (bone-marrow-derived) cell immunocytes in vitro, apparently via β -adrenergic receptors and adenylate cyclase activation. This polypeptide shows a high degree of evolutionary conservation, exhibiting close structural, functional, and immunological similarity when isolated from such diverse origins as cells of mammals and higher plants. This polypeptide was detected in animal cells, yeast, bacteria, and higher plants, and so may well be a universal constituent of living cells.

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