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Genetic Control of Endogenous C-Type Virus Production in Pancreatic Acinar Cells of C57BL/He and C57BL/6J Mice
Mauro Boiocchi, Gabriella Della Torre and Giuseppe Della Porta
Proceedings of the National Academy of Sciences of the United States of America
Vol. 72, No. 5 (May, 1975), pp. 1892-1894
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/64606
Page Count: 3
You can always find the topics here!Topics: Viruses, Pancreas, Acinar cells, Hybridity, Mice, Electron microscopy, Regulator genes, Pancreatic cells, Virions, Particle production
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Electron microscopy revealed very active production of C-type virus particles in the pancreatic acinar cells of untreated normal adult mice of the C57BL/He strain. In C57BL/6J mice, a similar picture was observed after a single intraperitoneal injection of dexamethasone. No viruses were observed in the pancreas of untreated or dexamethasone-treated BALB/c and C3Hf mice. F1 hybrids of both C57BL strains with C3Hf mice produced viruses in the same manner and quantity as the C57BL parents, whereas hybrids with BALB/c mice were entirely negative. Approximately 50% of mice of the first backcross generation of (BALB/c × C57BL/He)F1 hybrids with C57BL/He mice were active producers of C-type particles, while the other 50% were negative. It is suggested that a regulator gene that controls C-type virus production does not function in the pancreatic cells of either C57BL strain, and that BALB/c mice can provide hybrids with an active regulator.
Proceedings of the National Academy of Sciences of the United States of America © 1975 National Academy of Sciences