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Establishment of Tight Junctions between Epithelial Cells
A. J. Hudspeth
Proceedings of the National Academy of Sciences of the United States of America
Vol. 72, No. 7 (Jul., 1975), pp. 2711-2713
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/64791
Page Count: 3
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Epithelia serve as barriers to the diffusion of solutes between body compartments, and must do so despite the frequent loss of cells. When single cells are experimentally removed from the Necturus gallbladder epithelium, contiguous cells migrate to fill the defect within 30 min. Electrophysiological measurements show that the local electrical resistance across the epithelium in the region of a wound returns to normal in the same period of time; electron microscopy demonstrates that tight junctions are formed concurrently. Physiologically functional and morphologically recognizable tight junctions can thus be established within 30 min, demonstrating a mechanism for the rapid restoration of epithelial integrity after cell loss.
Proceedings of the National Academy of Sciences of the United States of America © 1975 National Academy of Sciences