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Rous sarcoma Virus Activates Embryonic Globin Genes in Chicken Fibroblasts

Mark Groudine and Harold Weintraub
Proceedings of the National Academy of Sciences of the United States of America
Vol. 72, No. 11 (Nov., 1975), pp. 4464-4468
Stable URL: http://www.jstor.org/stable/64977
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Rous sarcoma Virus Activates Embryonic Globin Genes in Chicken Fibroblasts
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Abstract

Complementary DNA (cDNA) specific for chick globin mRNA sequences fails to hybridize to total RNA extracted from chicken fibroblasts. After infection by Rous sarcoma virus, RNA complementary to globin cDNA is detectable in 100-500 copies per cell. Infection of fibroblasts with the transformation defective (td) deletion mutant of Rous sarcoma virus leads to normal virus production, but not to host cell transformation or accumulation of RNA sequences complementary to globin cDNA. Our evidence shows that the globin genes activated by Rous sarcoma virus are those specified by embryonic chick red cells; adult-specific globin sequences were not detected.

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