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Synthesis of Acetylcholine Receptor during Differentiation of Cultured Embryonic Muscle Cells
J. P. Merlie, A. Sobel, J. P. Changeux and F. Gros
Proceedings of the National Academy of Sciences of the United States of America
Vol. 72, No. 10 (Oct., 1975), pp. 4028-4032
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/65227
Page Count: 5
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Acetylcholine receptor, a component of the specialized muscle membrane, appears during the differentiation of embryonic myogenic cells in tissue culture. Demonstration of incorporation of the radioactive precursor L-[35S]methionine into purified receptor polypeptides is presented as evidence for its synthesis de novo. The identity of the purified radioactive species is established by cosedimentation of the [35S]receptor with [3H]α -toxin binding activity on sucrose gradients and by crossreaction with antiserum to purified acetylcholine receptor of Electrophorus electricus.
Proceedings of the National Academy of Sciences of the United States of America © 1975 National Academy of Sciences