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Synthesis of Acetylcholine Receptor during Differentiation of Cultured Embryonic Muscle Cells

J. P. Merlie, A. Sobel, J. P. Changeux and F. Gros
Proceedings of the National Academy of Sciences of the United States of America
Vol. 72, No. 10 (Oct., 1975), pp. 4028-4032
Stable URL: http://www.jstor.org/stable/65227
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Synthesis of Acetylcholine Receptor during Differentiation of Cultured Embryonic Muscle Cells
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Abstract

Acetylcholine receptor, a component of the specialized muscle membrane, appears during the differentiation of embryonic myogenic cells in tissue culture. Demonstration of incorporation of the radioactive precursor L-[35S]methionine into purified receptor polypeptides is presented as evidence for its synthesis de novo. The identity of the purified radioactive species is established by cosedimentation of the [35S]receptor with [3H]α -toxin binding activity on sucrose gradients and by crossreaction with antiserum to purified acetylcholine receptor of Electrophorus electricus.

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