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Characterization of a Delta-Electroencephalogram(-Sleep)-Inducing Peptide
Guido A. Schoenenberger and Marcel Monnier
Proceedings of the National Academy of Sciences of the United States of America
Vol. 74, No. 3 (Mar., 1977), pp. 1282-1286
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/66388
Page Count: 5
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A peptide that induces slow-wave (delta) and spindles electroencephalogram enhancement after intraventricular (brain) infusion has been isolated from rabbits and given the name delta-sleep-inducing peptide (DSIP). Amino acid sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. This compound, five possible metabolic products (containing residues 1-8, 2-9, 2-8, 1-4, and 5-9), two nonapeptide analogues with two amino acids exchanged, and a related tripeptide (Trp-Ser-Glu) were synthesized. All nine synthetic peptides were infused intraventricularly in rabbits under double-blind conditions. A total of 58 rabbits including controls were evaluated. The electroencephalogram leads from the neocortex and the archicortex were directly fast-Fourier transformed and analyzed by a Univac 1108 computer system. Only the delta-sleep-inducing peptide (synthetic) showed significant and specific enhancement/induction of delta and spindle electroencephalogram patterns.
Proceedings of the National Academy of Sciences of the United States of America © 1977 National Academy of Sciences